Anti-DPP6, clone 7G1.1

Application

Western Blotting Analysis: 0.5 µg/mL from a representative lot detected DPP6 in 10 µg of human fetal brain tissue lysate.

Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected DPP6 in human cerebral cortex, human cerebellum, rat cerebral cortex, and rat cerebellum tissue.

Research CategoryNeuroscience

Anti-DPP6 antibody, clone 7G1.1, Cat. No. MABN2186, is a highly specific mouse monoclonal antibody that targets DPP6 and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Dipeptidyl aminopeptidase-like protein 6 (UniProt: P42658; also known as DPPX, Dipeptidyl aminopeptidase-related protein, Dipeptidyl peptidase 6, Dipeptidyl peptidase IV-like protein, Dipeptidyl peptidase VI, DPP VI) is encoded by the DPP6 gene (Gene ID: 1804) in human. DPP6 is a type II membrane glycoprotein of the dipeptydilaminopeptidase-like proteins (DPPLs) subfamily. DPP6 has a short cytoplasmic domain, a long extracellular domain and a transmembrane domain. DPP6 is an inactive protease homolog that is an important regulator of CG cell excitability. It is widely expressed in the brain where it co-assembles with KCND2 channels and KChIP auxiliary subunits to regulate the amplitude and functional properties of the somatodendritic A-current, ISA. DPP6 is reported to promote cell surface expression of KCND2 and modulates it s the activity and gating characteristics. Defects in DPP6 gene have been linked to familial paroxysmal ventricular fibrillation 2, which is characterized by cardiac arrhythmia marked by fibrillary ventricular muscle contractions. In addition, DPP6 mutations are reported to cause mental retardation, autosomal dominant 33 (MRD33) characterized by mental retardation associated with microcephaly and impairments in adaptive behavior.

Immunogen

GST-tagged recombinant fragement corresponding to 72 amino acids from the N-terminal half of human DPP6.

Other Notes

Concentration: Please refer to lot specific datasheet.

Physical form

Protein G purified

Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Format: Purified

Quality

Evaluated by Western Blotting in mouse brain tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected DPP6 in 10 µg of mouse brain tissue lysate.

Specificity

Clone 7G1.1 detected DPP6 in mouse brain.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~100 kDa observed; 97.59 kDa calculated. Uncharacterized bands may be observed in some lysate(s).