Heregulin-B1 (EGF Domain) Human

Code: H7660-10UG D2-231

Analysis Note

The biological activity is measured by its ability to stimulate the proliferation of human MCF-7 cells grown under serum-free conditions.

Biochem/...


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Analysis Note

The biological activity is measured by its ability to stimulate the proliferation of human MCF-7 cells grown under serum-free conditions.

Biochem/physiol Actions

Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation. The phosphorylated receptors recruit cellular signaling proteins, initiating signaling pathways.

assay≥98% (SDS-PAGE)
biological sourcehuman
colorwhite
formlyophilized powder
Gene Informationhuman ... NRG1(3084)
impuritiesendotoxin, tested
mol wtpredicted mol wt 8 kDa
packagingpkg of 10 and 50 µg
potency﹤0.50 ng/mL
Quality Level200
recombinantexpressed in E. coli
storage conditionavoid repeated freeze/thaw cycles
storage temp.−20°C
UniProt accession no.Q02297
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