10058-F4, >=98% (HPLC), solid

Application

10058-F4 has been used:as c-Myc inhibitor to treat stromal cellsas c-Myc inhibitor to determine the effect of c-Myc inhibition on cardiac progenitor cells (CPC) growthas c-Myc inhibitor to culture T cellsto treat C4-2 cells to examine the activity of MST1 promoter luciferase reporter construct

Biochem/physiol Actions

10058-F4 is a c-Myc inhibitor that induces cell-cycle arrest and apoptosis. 10058-F4 is a cell-permeable thiazolidinone that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression. 10058-F4 inhibits tumor cell growth in a c-Myc-dependent manner both in vitro and in vivo (64 µM using c-Myc transfected Rat1a fibroblasts).

Features and Benefits

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Packaging

5, 25 mg in glass bottle