Rp-8-Bromo-beta-phenyl-1,N2-ethenoguanosine 3,5-cyclic monophosphorothioate sodium salt, >=98% (HPLC), powder

Name: Rp-8-Bromo-beta-phenyl-1,N2-ethenoguanosine 3,5-cyclic monophosphorothioate sodium salt, >=98% (HPLC), powder
Brand: SIGMA-ALDRICH
SKU: B6684-1MG
Price: 410.00 EUR

Code: B6684-1MG D2-231

Biochem/physiol Actions

Rp-8-Br-PET-cGMPS is metabolically stable, competitive inhibitor of cGMP-dependent protein kinase G. Inhibits both PKG I (K_i= 30 nM) and P...

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€333.33 1MG

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OVERVIEW
SPECIFICATIONS
DOCUMENTS
ATTRIBUTES

Biochem/physiol Actions

Rp-8-Br-PET-cGMPS is metabolically stable, competitive inhibitor of cGMP-dependent protein kinase G. Inhibits both PKG I (K_i= 30 nM) and PKG II and blocks cGMP-gated retinal type ion channels (IC₅₀= 25 micromoles).

Features and Benefits

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

U.S. Patent 5,625,056, DE Patent 4,217,679.

Packaging

1, 5 mg in glass bottle

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI key	SVMPQLHYWRTQCX-DBHVCDLJSA-M
InChI	1S/C18H15BrN5O6PS.Na/c19-17-21-11-14(24(17)16-12(25)13-10(29-16)7-28-31(27,32)30-13)22-18-20-9(6-23(18)15(11)26)8-4-2-1-3-5-8;/h1-6,10,12-13,16,25H,7H2,(H,20,22)(H,27,32);/q;+1/p-1/t10-,12-,13-,16-,31-;/m1./s1
mp	240-300 °C (lit.)
potency	30 nM K_i
Quality Level	100
SMILES string	O.[Na+].O[C@@H]1[C@@H]2O[P@]([O-])(=S)OC[C@H]2O[C@H]1n3c(Br)nc4C(=O)n5cc(nc5Nc34)-c6ccccc6
solubility	H₂O: 15 mg/mL at ≤60 °C
storage temp.	−20°C

Safety Data Sheet for B6684-1MG

Cas Number

185246-32-6

This product has met the following criteria to qualify for the following awards:

Rp-8-Bromo-beta-phenyl-1,N2-ethenoguanosine 3,5-cyclic monophosphorothioate sodium salt, >=98% (HPLC), powder

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