Application

Thianthrene S-oxide is a sulfoxide-based thianthrene reagent for late-stage C-H functionalization. Developed by the Ritter Lab, C-H functionalization by thianthrenation proceeds with >99% selectivity and furnishes functionalized arenes serving as synthetic linchpins for further participation in diverse transformations. Nonfluorinated thianthrene S-oxide is best used for all arenes more electron-rich than anisole. For other arenes, the fluorinated TFT S-oxide (903981) was demonstrated as the thanthrenation reagent.

Legal Information

Patent Application EP18204755.5 This product is manufactured pursuant to a license with Studiengesellschaft Kohle mbH

Other Notes

Site-selective and versatile aromatic C-H functionalization by thianthrenationVideo: Site-selective C-H functionalization by thianthrenationIn the Pipeline: New Chemistry, Making New ThingsTi(Phen)(OC₂H₅)₂Cl₂: a highly efficient pre-?catalyst for selective oxidation of organic sulfides to sulfoxides by hydrogen peroxide