25:0 COENZYME A

Application

25:0 Coenzyme A has been used as a constituent of the internal standard mixture in liquid chromatography-electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS).

25:0 Coenzyme A or pentacosanoyl Coenzyme A has been used as a substrate for 1-acylglycerol-3-phosphate-O-acyltransferase 11 (AGPAT11) enzyme. It has also been used as an internal standard to quantify fatty acyl CoA extracted from human embryonic kidney 293 cells.

Biochem/physiol Actions

Fatty acyl-CoA plays a vital role in various cellular processes including, energy metabolism, the biosynthesis and recycling of complex lipids, the posttranslational modification of proteins and the regulation of gene expression. In addition, it facilitates most of the fatty acid modification reactions. 25:0 coenzyme A might function as a precursor of sphingolipids. Alterations in the fatty acyl-CoA metabolism leads to obesity, cardiovascular disease, diabetes mellitis and cancer.

General description

25:0 Coenzyme A or pentacosanoyl coenzyme A is a long chain fatty acyl-CoA. Fatty acyl-CoAs is produced from de-novo fatty acid biosynthesis and the reprocessing of pre-existing fatty acids.

25:0 Coenzyme A, also known as pentacosanoyl coenzyme A, is a coenzyme derivative of pentacosanoic acid.

Packaging

5 mL Amber Glass Screw Cap Vial (870729P-5mg)