Application

C16 Ceramide (d18:1/16:0) has been used:as an internal standard in the chromatography with negative ion electrospray ionization coupled to tandem mass spectrometry for myocardial ceramide quantificationas an internal standard for the ceramide quantification from rat samples using liquid chromatography-mass spectrometryto test its effect on mitochondrial stress response in worms

Biochem/physiol Actions

C16 Ceramide levels are elevated in chronic alcohol-related liver disease (ALD). In general, ceramide inhibits mitochondrial function and insulin signaling. They are essential component of cell membrane and are involved in lipid raft formation. C16 ceramide based analog (C2-C16 CCPS) is potential anticancer agent used in chemotherapy. The levels of C16 ceramide and its ratio with other ceramides is regarded as a biomarker in predicting coronary artery disease (CAD). It interacts with the DNA-binding domain of tumor suppressor protein p53 and activates p53.

General description

Ceramide comprise sphingosine and fatty acid and belongs to the sphingolipids family.

Packaging

5 mL Amber Glass Screw Cap Vial (860516P-100mg)

5 mL Amber Glass Screw Cap Vial (860516P-50mg)

5 mL Amber Glass Screw Cap Vial (860516P-25mg)

5 mL Amber Glass Screw Cap Vial (860516P-10mg)

5 mL Amber Glass Screw Cap Vial (860516P-5mg)