C4 CERAMIDE (D18:1/4:0)

Application

C4 Ceramide (d18:1/4:0) has been used to study its role in rescuing and stabilizing ΔF508-cystic fibrosis transmembrane conductance regulator (ΔF508-CFTR).

Biochem/physiol Actions

C4 Ceramide (d18:1/4:0) is implicated in a series of mutual autophosphorylation and phosphorylation actions between 3-phosphoinositide-dependent kinase 1 (PDK1) and serum/glucocorticoid-induced protein kinase 1 (SGK1). It stimulates cyclic adenosine monophosphate (cAMP)-activated chloride secretion and represses hypersecretion of interleukin-8 (IL-8). C4 Ceramide might be a potential therapeutic for cystic fibrosis (CF).

General description

C4 Ceramide (d18:1/4:0) or N-butyroyl-D-erythro-sphingosine is a synthetic ceramide containing sphingosine with butyricacid. It is a non-toxic, short-chain sphingolipid.

Packaging

5 mL Amber Glass Screw Cap Vial (860504P-5mg)