Application

Ganglioside GM3 (Bovine Milk) has been used inlipid binding assay to assess the binding of monoclonal antibodies (mAbs). It may be used as a standard to investigate the efficiency of ganglioside extraction in brain using electrospray ionization-mass spectrometry (ESI MS) analysis. It may also be used for the structural characterization of gangliosides using ultraviolet photodissociation mass spectrometry.

Biochem/physiol Actions

Ganglioside monosialodihexosylganglioside (GM3)blocks the activity of fibroblast growth factor receptor. GM3-enriched microdomain is involved in modulating cell growth. Low levels of gangliosideGM3 is involved in the pathogenesis ofrheumatoid arthritis. GM3 regulatesimmunologicalfunctions by preventing cytokine production. It regulates apoptosis, cell proliferation and differentiation. GM3 is also involved in cellular signaling pathways, cell adhesion and mobility. Increased GM3 levels are associated with diabetic nephropathy.

General description

Ganglioside monosialodihexosylganglioside (GM3)are glycosphingolipids (GSLs), which are membrane-bound consisting ofasialic acid residueand an oligosaccharide head structure. It is found in milk and kidney cells. GM3is the most broadly distributed ganglioside in tissues.

Packaging

5 mL Amber Glass Screw Cap Vial (860058P-25mg)

5 mL Amber Glass Screw Cap Vial (860058P-1mg)

5 mL Amber Glass Screw Cap Vial (860058P-5mg)

5 mL Amber Glass Screw Cap Vial (860058P-10mg)