Application

Ganglioside-Total may be used: as a standard toinvestigatethe efficiency ofgangliosideextractionin brain using electrospray ionization-mass spectrometry (ESI MS) analysisas a hemagglutinin (HA) binding receptor to assemble nanodisc with affinity to influenza virus (NDTG) and also to determine the effect of total ganglioside extract (TG) amount on total gangliosidein liposomes to measureostreolysinA (OlyA) binding in order todeducethe effects ofphosphatidylcholines(PCs) onsphingomyelin

Biochem/physiol Actions

Gangliosides regulate various biological activities in cell plasma membranes (PMs). It provides structural rigidity to the cell. Ganglioside clusters form membrane microdomains, which facilitates cell adhesion. It also functions as differentiating markers during oncogenesis, embryogenesis, lymphoid differentiation and neoplastic transformation. Gangliosides have the ability to repress cell-mediated immune functions. It is also associated with cancer and Alzheimer′s disease.

General description

Gangliosides are glycosphingolipids, that contain sialic acid residues in the glycan chain. They are mainly present on the surface of neuronal cells. Gangliosides are also present in serum. Four complex ganglioside structures, such as GM1, GD1a, GD1b and GT1b are the most abundantly found ganglioside in mammalian brains. Gangliosides comprise a ceramidetail attached to a polar carbohydrate head.

Packaging

5 mL Amber Glass Screw Cap Vial (860053P-50mg)

5 mL Amber Glass Screw Cap Vial (860053P-25mg)

5 mL Amber Glass Screw Cap Vial (860053P-10mg)