Application

W146 has been used:to verify the mode of action of sphingosine-1-phosphate (S1P) in human bone marrow derived mesenchymal stem cells (hMSCs ) and primary human hepatogenic profibrotic cells (hHPCs) to study oxidative stress and drug treatment in granulosa cells to evaluate its effects on transendothelial electrical resistance (TEER)

Biochem/physiol Actions

W146 acts as an orthosteric antagonist. It is linked to blood lymphopenia and lung edema in mice.

General description

W146 is a sphingosine-1-phosphate 1 (S1P1) selective antagonist.

Compound 2a is a selective antagonist for human S1P1 (hS1P1) receptor activation by the physiological agonist S1P.

Packaging

5 mL Amber Glass Screw Cap Vial (857390P-10mg)

5 mL Amber Glass Screw Cap Vial (857390P-1mg)