08:0 PI(4 5)P2

Code: 850185P-100UG D2-231

Application

08:0 PI(4,5)P2 is suitable for use to identify its binding site in transientreceptor potential vanilloid 4 (TRPV4N) terminus. It has been used in in vitro

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€95.34 100UG
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Application

08:0 PI(4,5)P2 is suitable for use to identify its binding site in transientreceptor potential vanilloid 4 (TRPV4N) terminus. It has been used in in vitro binding assay to determine the binding of G-protein coupled receptor kinases (GRKs) and β2-adrenergic receptor (β2AR).

General description

Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT. The dioctanoyl derivative of PI(4,5)P2 is more water soluble than its long chain counterparts.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (850185P-100ug)

2 mL Amber Serum Vial with Stopper and Crimp Cap (850185P-500ug)

assay>99% (TLC)
formpowder
manufacturer/tradenameAvanti Polar Lipids 850185P
packagingpkg of 1 × 100 µg (with stopper and crimp cap (850185P-100ug)), pkg of 1 × 500 µg (with stopper and crimp cap (850185P-500ug))
shipped indry ice
SMILES string[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1O)=O)(OC(CCCCCCC)=O)COC(CCCCCCC)=O.[NH4+].[NH4+].[NH4+]
storage temp.−20°C
Cas Number852043-37-9
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