18:0 PA

Application

18:0 PA may be used:as a component in the bilayer to study its vesiculation ability on different coat protein I (COPI) fission factorto study its effects on intracellular Ca²⁺concentration ([Ca^2+]i) in C6 rat glioma and L2071 mouse fibroblast cells to study its effects on phosphorylation of cytochrome b(558) alpha chain (p22phox)

Biochem/physiol Actions

Phosphatidic acid (PA) acts as a biosynthetic precursorfor the production of membrane glycerophospholipid and triacylglycerol. It participates in the modulation of mammalian target of rapamycin (mTOR) pathway. It may also participate in membrane trafficking, specifically in membrane fusion and fission.

General description

Phosphatidic acid (PA) has two fatty acids and one phosphate group attached to a glycerol backbone. The two fatty acids are present at positionsn-1 andsn-2 of the C-atoms and the phosphate group is present in the sn-3 position of the C-atom.

Packaging

5 mL Amber Glass Screw Cap Vial (830865P-25mg)

20 mL Clear Glass Screw Cap Vial (830865P-500mg)