Biochem/physiol Actions

Cell permeable: no

Reversible: yes

Product does not compete with ATP.

Target IC₅₀: 648 nM in blocking IP3-mediated Ca2+ release

Primary TargetIP3-mediated Ca2+

General description

A reversible, membrane-permeable blocker of IP₃-mediated Ca²⁺ release (IC₅₀ = 648 nM). Also displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (RyR-1).

A membrane-permeable, reversible blocker of IP₃-mediated Ca²⁺ release (IC₅₀ = 648 nM) that is less potent than XeC (Cat. No. 682160). Also displays a high selectivity over the skeletal isoform of the ryanodine receptor type 1 (Ry1R).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Gafni, J., et al. 1997. Neuron 19, 723.Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111.Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876.Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505.Nakagawa, M., et al. 1984. Tetrahedron Lett.25, 3227

Packaging

50 µg in Plastic ampoule

Preparation Note

Sonication may be required to achieve complete solubilization.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Harmful (C)