Biochem/physiol Actions
Cell permeable: no
Reversible: yes
Product does not compete with ATP.
Target IC50: 648 nM in blocking IP3-mediated Ca2+ release
Primary TargetIP3-mediated Ca2+
General description
A reversible, membrane-permeable blocker of IP3-mediated Ca2+ release (IC50 = 648 nM). Also displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (RyR-1).
A membrane-permeable, reversible blocker of IP3-mediated Ca2+ release (IC50 = 648 nM) that is less potent than XeC (Cat. No. 682160). Also displays a high selectivity over the skeletal isoform of the ryanodine receptor type 1 (Ry1R).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Gafni, J., et al. 1997. Neuron 19, 723.Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111.Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876.Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505.Nakagawa, M., et al. 1984. Tetrahedron Lett.25, 3227
Packaging
50 µg in Plastic ampoule
Preparation Note
Sonication may be required to achieve complete solubilization.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Warning
Toxicity: Harmful (C)
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