MG Wnt Agonist I in DMSO 1PC X 2MG

Biochem/physiol Actions

Reversible: yes

Cell permeable: yes

General description

A cell-permeable, potent, and selective activator of Wnt signaling that does not inhibit the activity of GSK-3β (IC₅₀ >60 µM). Shown to mimic the effect of Wnt and induce β-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC₅₀ = 700 nM in HEK-293T cells). Reported to cause substantial head defects during Xenopus embryonic development. The solid form of this compound (Cat. No. 681665) is also available.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Liu, J., et al. 2005. Angew. Chem. Int. Ed.44, 1987.

Packaging

Packaged under inert gas

2 mg in Glass bottle

Physical form

A 25 mM (2 mg/228 µL) solution of Wnt Agonist I (Cat. No. 681665) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

Warning

Toxicity: Irritant (B)