Vincristine Sulfate; Apocynaceae sp.

Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

General description

Indole alkaloid that binds to tubulin, inhibiting formation of microtubules. Depolymerizes microtubules. Induces increase in micronuclei and delays cell cycle progression. Anti-neoplastic agent. Induces apoptosis in human lymphoma cells by disrupting microtubules.Please note that the molecular weight for this compound is batch-specific due to variable water content.

Indole alkaloid that binds to tubulin, inhibiting the formulation of microtubules. Depolymerizes microtubules. Induces an increase in the micronucleus and delays cell cycle progression. Antineoplastic agent. Induces apoptosis in human lymphoma cells by distributing microtubules.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Chan, M.W., et al. 1998. Cancer Biochem. Biophys. 16, 347.Hanauske, A.R., et al. 1994. Eur. J. Cancer30A, 1688.Takano, Y., et al. 1993. Pathol. Res. Pract. 189, 187.

Packaging

10 mg in Plastic ampoule

Warning

Toxicity: Carcinogenic / Teratogenic (D)