Tunicamycin; Streptomyces lysosuperficus

Biochem/physiol Actions

Secondary Targetthrombin-induced Ca²⁺ mobilization in cells

Primary TargetN-linked glycosylation

General description

A nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against gram-positive bacteria, yeasts, fungi, and viruses. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca²⁺ mobilization in cells.

A nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against Gram-positive bacteria, yeasts, fungi, and viruses. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca²⁺ mobilization in cells. Also available as a 25 mM solution in DMSO (Cat. No. 504570).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Tordai, A., et al. 1995. Biochem. Biophys. Res. Commun. 206, 857.Price, B.D., et al. 1992. J. Cell Physiol.152, 545.

Packaging

50 mg in Alu drum

10 mg in Glass bottle

Preparation Note

Aqueous solutions can be prepared from DMSO stock solutions by diluting in H₂O at pH 8.0 to 10.0 or with appropriate buffers at pH >7.0.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.

Aqueous solutions can be prepared from stock solutions in DMSO by diluting with H₂O at pH 8.0 to 10.0 or with appropriate buffers at pH >7.0 (preferably >8.0).

Warning

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)