Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Target IC₅₀: 6.5 µM inhibiting human telomerase

General description

A potent inhibitor of human telomerase (IC₅₀ = 6.5 µM). TMPyP4 binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition. Fluoresces intensely in the presence of quadruplex DNA.

A potent inhibitor of human telomerase (IC₅₀ = 6.5 µM). TMPyP4 binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition. Fluoresces highly in the presence of quadruplex DNA.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Yamashita, T., et al. 2005. Bioorg. Med. Chem.13, 2433.Izbicka, E., et al. 1999. Cancer Res. 59, 639.Anantha, N.V., et al. 1998. Biochemistry 37, 2709.Arthanari, H., et al. 1998. Nucleic Acids Res. 26, 3724.Wheelhouse, R.T., et al. 1998. J. Am. Chem. Soc. 120, 3261.

Packaging

25 mg in Plastic ampoule

Warning

Toxicity: Standard Handling (A)