Spermine; Tetrahydrochloride

Biochem/physiol Actions

Secondary TargetnNOS

Primary Targetphospholipase C α

General description

Polyamine that plays an important role in the regulation of cellular proliferation and differentiation. Acts as an inhibitor of phopholipase C-α and an activator of phopholipase C-δ. Has both stimulatory and inhibitory effects on NMDA receptors depending on the subunit composition of the receptor. Inhibits neuronal NOS. Inhibits DNA fragmentation and morphological apoptosis.

Polyamine that plays an important role in the regulation of cellular proliferation and differentiation. Has both stimulatory and inhibitory effects on NMDA receptors depending on the subunit composition of the receptor. Acts as an inhibitor of phospholipase Cα and an activator of phospholipase Cδ. Inhibits DNA fragmentation and morphological apoptosis. Inhibits neuronal NOS.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Igarashi, K. and Williams, K. 1995. J. Pharmacol. Exp. Ther. 272, 1101.Escargueil-Blanc, I., et al. 1994. FASEB J.8, 1075.Hu, J., et al. 1994. Neurosci. Lett. 175, 41.Tompkins, T.A. and Moscarello, M.A. 1994. Biochim. Biophys. Acta1206, 1208.Trubiani, O., et al. 1994. Biochem. Mol. Biol. Int.32, 1085.Svensson, F., et al. 1993. Mol. Cell. Biochem.124, 141.Ask, A., et al. 1992. Cancer Lett.66, 29.Chida, N., et al. 1992. Brain Res.593, 57.Khan, A.U., et al. 1992. Proc. Natl. Acad. Sci. USA89, 11428.Messena, L., et al. 1992. J. Leukoc. Biol. 52, 585.Pawelczyk, T., et al. 1992. Arch. Biochem. Biophys.297, 328.Shantz, L.M., et al. 1992. Biochem. J.288, 511.

Packaging

5 g in Plastic ampoule

Reconstitution

Following reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C under inert gas.

Warning

Toxicity: Irritant (B)