SOD1 Inhibitor; LCS-1

Code: 567417-10MG D2-231

General description

A 2-phenylpyridazin-3(2H)-one based non-copper chelater that selectively inhibits the activity of Superoxide dismutase 1 (Cu/Zn-SOD) (IC50 = 1....


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Your Price
€226.99 10MG
Discontinued
€279.20 inc. VAT

General description

A 2-phenylpyridazin-3(2H)-one based non-copper chelater that selectively inhibits the activity of Superoxide dismutase 1 (Cu/Zn-SOD) (IC50 = 1.07 µM). Cells over-expressing SOD1 show reduced sensitivity to LCS-1. Shown to preferably inhibit the growth of a variety of human lung adenocarinoma cell lines with EGFR and KRAS mutations (IC50 = 200 nM). Prevents serum-induced activation of the ERK and PI 3-kinase/AKT signaling thereby affecting cell growth and survival. Apparent half-life of this compound is reported to be 6.6 min in human liver microsomes.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Somwar, R., et al. 2011, PNAS in press.Somwar, R., et al. 2009. J. Biomol. Screen14, 1176

Packaging

Packaged under inert gas

10 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)

assay≥99% (HPLC)
colorwhite
formsolid
manufacturer/tradenameCalbiochem®
Quality Level100
shipped inambient
solubilityDMSO: 50 mg/mL, clear, colorless
storage conditionprotect from light, OK to freeze
storage temp.−20°C
Cas Number41931-13-9
This product has met the following criteria to qualify for the following awards:



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