SKF-525A; Hydrochloride

Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary TargetnNOS

Cell permeable: yes

Target IC₅₀: 90 µM against neuronal nitric oxide synthase

General description

Cell permeable. Blocks glibenclamide-sensitive K⁺ channels (IC₅₀ = 4.4 µM). Inhibits neuronal nitric oxide synthase (IC₅₀ = 90 µM). Also inhibits hepatic drug metabolism by inhibiting the cytochrome P-450 system. Stimulates endothelial cell prostocyclin production while inhibiting platelet thromboxane synthesis. Potentiates the effect of many drugs in vivo.

Cell permeable. Blocks glibenclamide-sensitive K⁺ channels. Inhibits neuronal nitric oxide synthase (IC₅₀ = 90 µM). Also inhibits hepatic drug metabolism by inhibiting the cytochrome P450 system. Stimulates endothelial cell prostacyclin production while inhibiting platelet thromboxane synthesis. Potentiates the action of many drugs in vivo.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Hecker, M., et al. 1994. J. Neurochem. 62, 1524.Sakuta, H. and Yoneda, I. 1994. Eur. J. Pharmacol.252, 117.Khan, S., et al. 1993. Biochem. Pharmacol.45, 439.Boeynaems, J.M., et al. 1986. Prostaglandins32, 145.Lee, C.H., et al. 1976. J. Pharmacol. Exp. Ther.198, 347.Grasdalen, J., et al. 1975. FEBS Lett.60, 240.

Packaging

1 g in Plastic ampoule

Reconstitution

Following reconstitution, store in the refrigerator(4°C). Stock solutions are stable for up to 6 months at 4°C.

Warning

Toxicity: Harmful (C)