Biochem/physiol Actions

Reversible: no

Target IC₅₀: >5 µM, >50 µM and >50 µM for SIRT3, SIRT1 and SIRT2

Product does not compete with ATP.

Primary TargetSirtuin 3

Cell permeable: yes

General description

A cell-permeable structural isomer of SIRT2 Inhibitor, AGK2 (Cat. No. 566324) that selectively inhibits sirtuin 3 over sirtuins 1 and 2 (IC₅₀ = >5 µM, >50 µM and >50 µM for SIRT3, SIRT1 and SIRT2, respectively) and poorly affects both α-synuclein-mediated toxicity and α-Syn aggregation in α-Syn-H4 cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Outerio, T.F., et al. 2007. Science317, 516.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Warning

Toxicity: Regulatory Review (Z)