#-SECRETASE INHIBITOR VI 1PC X 5MG

Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Target IC₅₀: 1.8 µM against Aβ42 production

Primary TargetAβ₄₂ production

Cell permeable: yes

General description

A potent, cell-permeable inhibitor of γ-secretase that blocks the formation of Aβ₄₂ (IC₅₀ = 1.8 µM). Treatment of HEK293 cells with γ-secretase inhibitor VI results in an increase in β-secretase-cleaved, APP fragments and secreted APP_Sα, but no change in secreted APP_Sβ, indicating a specific inhibition of γ-secretase activity.

Cell permeable. Potently inhibits Aβ₄₂ production (IC₅₀ = 1.8 µM). Treatment of HEK293 cells with this inhibitor results in β-Secretase-cleaved APP fragments and secreted APPα, but no change in secreted APPsβ is observed indicating specific inhibition of γ-secretase.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Rishton, G.M., et al. 2000. J. Med. Chem.43, 2297.

Packaging

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze at (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Standard Handling (A)