trans-4-Hydroxy-L-proline, BioXtra, >=99.0% (NT)

Code: 56250-25G D2-231

Biochem/physiol Actions

Trans-4-Hydroxy-L-proline is used as a starting material in the synthesis of (-)-secrinine; the synthesis of prolinol-based nucleotide analogues with ...


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Biochem/physiol Actions

Trans-4-Hydroxy-L-proline is used as a starting material in the synthesis of (-)-secrinine; the synthesis of prolinol-based nucleotide analogues with N-phosphonomethyl moiety attached to the nitrogen atom of prolinol ring and in asymmetric synthesis of the ABC-ring system of the antitumor antibiotic MPC1001.

Trans-4-Hydroxy-L-proline is used in the organic synthesis of depsilairdin analogues, noncompetitive peptidomimetic inhibitors of multidrug resistance P-glycoprotein and 3-guaninyl-5-hydroxymethyl-2-pyrrolidinone (4) or 3-adeninyl-5-hydroxymethyl-2-pyrrolidinone (5) nucleoside analogues.

Other Notes

Natural constituent of animal structural proteins such as collagen and elastin.

Enzymes and intermediates of hydroxyproline degradation

anion tracessulfate (SO42-): ≤100 mg/kg, chloride (Cl-): ≤100 mg/kg
application(s)peptide synthesis
assay≥99.0% (NT)
cation tracesNa: ≤50 mg/kg, K: ≤50 mg/kg, Cr: ≤5 mg/kg, Mn: ≤5 mg/kg, Mg: ≤5 mg/kg, Ca: ≤10 mg/kg, Pb: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, NH4+: ≤100 mg/kg, Zn: ≤5 mg/kg, Ni: ≤5 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg
colorcolorless to white
formsolid
ign. residue≤0.1% (as SO4)
impurities≤0.3% foreign amino acids
InChI keyPMMYEEVYMWASQN-DMTCNVIQSA-N
InChI1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
loss≤0.1% loss on drying, 110 °C
mp273 °C (dec.) (lit.)
optical activity[α]20/D −76.0±1.5°, c = 5% in H2O
product lineBioXtra
Quality Level100
SMILES stringO[C@H]1CN[C@@H](C1)C(O)=O
Cas Number51-35-4
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