Biochem/physiol Actions

Primary TargetDNA-dependent RNA polymerase in bacteria

General description

Antibiotic that specifically inhibits DNA-dependent bacterial RNA polymerase by forming an inactive complex with RNA polymerase. Does not affect mammalian RNA polymerase. Inhibits transcription by preventing the initial transcription complex from entering the elongation mode.

Antibiotic that specifically inhibits DNA-dependent RNA polymerase in bacteria by forming an inactive complex. Does not affect mammalian RNA polymerase. Inhibits transcription by preventing the initial transcription complex from entering the elongation mode.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Jin, D.J. and Turnbough, Jr., C.L. 1994. J. Mol. Biol. 236, 72.Levin, M.E. and Hatfull, G.F. 1993. Mol. Microbiol. 8, 277.Wehrli, W., et al. 1968. Proc. Natl. Acad. Sci. USA61, 667.

Packaging

5 g in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 2 months at -20°C.

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)