General description

Potent modulator of growth and differentiation. Exerts its effects by binding to nuclear retinoic acid receptors (RARs) which directly regulate gene expression. Inhibits melanocyte adhesion, motility, and growth. Has keratolytic activity. Induces differentiation of tumor cells of neural origin. Induces apoptosis in acute promyelocytic carcinoma cells.

Potent modulator of growth and differentiation. Exerts its effects by binding to nuclear retinoic acid receptors (RARs) which directly regulate gene expression. Inhibits melanocyte adhesion, motility, and growth. Has keratolytic activity. Induces differentiation of tumor cells of neural origin. Induces apoptosis in acute promyelocytic carcinoma cells. PROTECT FROM AIR.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Tosi, P., et al. 1994. Leuk. Lymphoma14, 503.Clagett-Dame, M., et al. 1993. Arch. Biochem. Biophys.300, 684.Labbaye, C., et al. 1993. Blood81, 475.Sakashita, A., et al. 1993. Blood81, 1009.Situ, R., et al. 1993. Dermatology186, 38.Tini, M., et al. 1993. Genes Develop.7, 295.Leid, M., et al. 1992. Trends Biochem. Sci.17, 427.Sharpe, C.R. 1991. Neuron7, 239.Thaller, C. and Eichele, G. 1990. Nature345, 815.

Packaging

Packaged under inert gas

500 mg in Glass bottle

Reconstitution

Following reconstitution, store in the refrigerator (4°C). DMSO stock solutions are stable for up to 2 weeks at 4°C.

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)