Biochem/physiol Actions
Reversible: no
Product does not compete with ATP.
Primary TargetRas/Rac
Cell permeable: yes
General description
A cell-permeable pyrazoloquinoline compound that acts as an effective blocker of Ras-induced malignant transformation and inhibits Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex and membrane ruffling. The effect of SCH 51344 is limited to Ras/Rac pathway(s) other than those involving ERK and JNK. Shown to directly target human mutT homolog MTH1/NUDT1 with a Kd of 49 nM and inhibit its catalytic activity (IC50 for pyrophosphate release during nucleotide triphosphate hydrolysis = 215, 410 and 675 nM against dGTP, 8-oxo-dGTP and 2-OH-dATP substrates, respectively).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Huber, K. V. M., et al. 2014. Nature In press.He, H., et al. 1998. Mol. Cell. Biol.18, 3829.Walsh, A.B., et al. 1997. Oncogene15, 2553.Chandra Kumar, C., et al. 1995. Cancer Res.55, 5106.
Packaging
Packaged under inert gas
10 mg in Plastic ampoule
Warning
Toxicity: Standard Handling (A)
This product has met the following criteria to qualify for the following awards: