Biochem/physiol Actions

Reversible: yes

Primary TargetTRPML3

Cell permeable: yes

General description

A non-cytotoxic morpholinyl-cyclohexylbenzenesulfonamide compound that acts as a selective agonist of TRPML3 channel (EC₅₀ = 873 nM in hTRPML3-YPF transfected HEK293 cells). Displays significantly weaker agonistic activity for TRPML2 channel (54.5% at 10 µM) and is shown to be inactive against hTRPML1, hTRPM2, mTRPV2, hTRPC3, drTRPN1, and hTRPA1 (~10 µM). Also binds to sigma-1 receptor at much higher concentrations (IC₅₀ = 31 µM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Antolin, A.A., and Mestres, J. 2015. ACS Chem. Biol.10, 395.r>Grimm, C., et al. 2012. J. Biol. Chem.287, 22701.Saldanha, S., et al. 2010. Probe Reports from the NIH Molecular Libraries Program.Grimm, C., et al. 2010. Chem. Biol.17, 135.

Packaging

25 mg in Glass bottle

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)