General description
A cell-permeable isoquinolinedione compound that potently inhibits PARP-1 activity (pIC50 = 7.35; IC50 = 45 nM) in a NAD+-competitive and reversible manner, while affecting PPAR-2 activity with a 100-fold lower potency. Selectively inhibits PARP-1-mediated cellular PAR formation and is of little effect against PAR formation in fibroblasts derived from parp-1(-/-) mice. Its in vivo application is limited by a poor aqueous solubility (~9 µM).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Eltze, T., et al. 2008. Mol. Pharmacol.74, 1587.
Packaging
Packaged under inert gas
10 mg in Plastic ampoule
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Warning
Toxicity: Standard Handling (A)
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