Biochem/physiol Actions

Primary TargetASIC1a

General description

A potent proton-gated sodium channel (ASIC1a) channel blocking neurotoxin (IC₅₀ = 0.9 nm) isolated from the Trinidad chevron tarantula. Psalmotoxin-1 (PcTx1) can distinguish between the two ASIC1 splice variants, ASIC1a and ASIC1b. Binding site is blocked when dimerization with ASIC2a or ASIC3.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Qadri, Y. J. et al. 2009. J. Biol. Chem.284, 17625.M. Mazzuca, et al. 2007. Nat Neurosci.10, 943.Escoubas, P. et al. 2000. J. Biol. Chem.275, 25116.

Packaging

20 µg in Glass bottle

Sequence

EDCIPKWKGCVNRHGDCCEGLECWKRRRSFEVCVPKTPKT (disulfide bond 3-18, 10-23, 17-33)

Warning

Toxicity: Standard Handling (A)