Biochem/physiol Actions

Primary TargetCa_v2.3 channels

General description

A peptidyl toxin present in the venom of African tarantula, Hysterocrates gigas that acts as a high affinity, reversible blocker of Ca_v2.3 (α1E, R-type) channels (IC₅₀ = 15-30 nM). The inhibition appears to be voltage-dependent. At lower concentrations it is also shown to block native R-type Ca2+ current in rat neurohypophyseal nerve terminals, however, these effects are not observed at higher concentrations. Does not affect Na+ or K+ currents in several cultured cell types (~ 500 nM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Abitbol, K. et al. 2012. J. Physiol.590, 2977.Newcomb, R., et al., 1998. Biochemistry.37, 15353.

Packaging

10 µg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sequence

GVDKAGCRYMFGGCSVNDDCCPRLGCHSLF→SYCAWDLTFSD (difulfid bond: 7-21, 14-26, 20-33)

Warning

Toxicity: Standard Handling (A)