Biochem/physiol Actions

Primary TargetDAT

General description

A potent inhibitor of dopamine active transporter (DAT, K_i = 1 nM, IC₅₀ = 40 and 51 nM) with >100 fold selectivity over noradrenalin and 5-HT re-uptake transporter. Shown to produce behavioral profile in mice for bipolar mania disease model and ADHD disease models.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Young, J. et al. 2010. Psychopharm.208, 443.r>Hewitt, K., et al. 2009. Neuropharm.57, 678.Prisinzano, T. et al. 2002. J. Med. Chem.45, 4371.Andersen, P., et al. 1989. Eur. J. Pharmacol.166, 493.Heikkila, R., et al. 1984. Eur. J. Pharmacol.103, 142.

Packaging

10 mg in Glass bottle

Preparation Note

Slight warming is required for complete solubilization.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)