Biochem/physiol Actions

Primary TargetGluN1/NR2B receptors

General description

A potent, activity-dependent antagonist highly selective for GluN1/NR2B subtype NMDA receptors (IC50 = 0.009 and 52 µM for NR2B and NR2A subtype receptors respectively). Commonly used for studying brain functions and disorders involving neurotransmissions mediated by GluN1/NR2B subtype NMDA receptors (learning and memory, neuroplasticity, neurotoxicity, neuropathic pain, addiction, and neurogenesis enhancement).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Qi, Y., et al. 2013. Cereb. Cortex.23, 932.Soloviova, A., et al. 2012. Exp. Biol. & Med.153, 764.Solovyeva, A., et al. 2012. Neurosci. & Behav. Physiol.42, 456.Chazot, L., et al. 2004. Curr. Med. Chem.11, 389.Lynch, R., et al. 2001. Eur. J. Pharmacol.416, 185.Fischer, G., et al. 1997. J. Pharmacol. Exp. Ther.283, 1285.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)