Biochem/physiol Actions

Primary TargetmGlu₇ receptors

General description

A potent, selective and systemically active positive allosteric modulator for mGlu₇ receptor (EC₅₀ = 64-290 nM). One of the most frequently used agent for assessing the functional roles of mGlu₇ receptors in a variety of brain functions (i.e. sleep pattern, learning and memory, and locomotion) and disorders (i.e. depression, anxiety, and Parkinson’;s disease). Induces internalization of mGlu₇ receptors. Also acts on NMDA, AMPA, 5-HT receptors and norepinephrine transporter.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Cavas, M., et al. 2013. Pharmacol. Biochem. Behav. 103, 756.Sukoff, R., et al. 2011. J. Pharmacol. Exp. Ther. 338, 345.r>Flor, X., et al. 2005. Neuropharmacology 49, 244.Mitsukawa, K., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 12.r>Greco, B., et al. 2010. J. Pharmacol. Exp. Ther. 332, 1064.r>Pelkey, K., et al. 2007. Neuropharmacology. 52, 108.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)