Biochem/physiol Actions

Primary TargetmGlu₁ receptors

General description

A potent antagonist selective for mGlu_1a receptors (IC₅₀ = 8.8 µM and >100 µM for mGlu_1a and mGlu_5a, respectively). Negligible effect on group II and III mGlu receptors. Frequently used in studies assessing the functional roles of mGlu_1a in various brain functions and disorders in which neural transmissions via mGlu_1a receptors are involved.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Young, R., et al. 2013. J. Neurosci.33, 2526.Chapman, A., et al. 1999. Eur. J. Pharmacol.368, 17.Bruno, V., et al. 1999. Neuropharmacol.38, 199.r>Clark, X., et al. 1997. Bioorg. Med. Chem. Lett.7, 2777.

Packaging

5 mg in Glass bottle

Physical form

Supplied as a hydrochloride salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)