Mycophenolic Acid

Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetInosine monophosphate dehydrogenase

General description

An immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of inosine monophosphate dehydrogenase and prevents the formation of XMP and GMP. Useful for selection of animal cells that express the E. coli gene coding for xanthine-guanine phosphoribosyltransferase. Also suppresses cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells.

An immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of IMP dehydrogenase and prevents the formation of XMP and GMP. Useful for selection of animal cells that express the E. coli gene coding for xanthine-guanine phosphoribosyltransferase. Also suppresses cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Langman, L.J., et al. 1995. Clin. Chem. 41, 295.Senda, M., et al. 1995. Transplantation60, 1143.Warner-Bartnicki, A.L., et al. 1993. Exp. Cell Res.204, 241.Falkner, F.G., and Moss, B. 1988. J. Virol.62, 1849.Cohen, M.B., et al. 1981. J. Biol. Chem.256, 8713.Mulligan, R.C., and Berg, P. 1981. Proc. Natl. Acad. Sci. USA78, 2072.

Packaging

100, 500 mg in Plastic ampoule

Reconstitution

Following reconstitution, sterilize by filtration through a 0.22 µm pore-size filter, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)