Biochem/physiol Actions

Reversible: no

Target IC₅₀: 300 nM for rat neuronal nitric oxide synthase

Product does not compete with ATP.

Cell permeable: yes

Primary TargetRat neuronal nitric oxide synthase

General description

A cell-permeable, inhibitor of nitric oxide synthase that exhibits about 17-fold greater selectivity for rat neuronal nitric oxide synthase (IC₅₀ = 300 nM) compared to the endothelial enzyme (IC₅₀ = 5.4 µM).

A cell-permeable inhibitor of nitric oxide synthase that exhibits about 17-fold greater selectivity for rat neuronal nitric oxide synthase (IC₅₀ = 300 nM) compared to the endothelial enzyme (IC₅₀ = 5.4 µM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Krishnaswamy, N., et al. 1995. J. Biol. Chem.270, 11103.Furfine, E.S., et al. 1994. J. Biol. Chem. 269, 26677.Narayanan, K., and Griffith, O.W. 1994. J. Med. Chem.37, 885.

Packaging

Packaged under inert gas

10 mg in Plastic ampoule

Warning

Toxicity: Standard Handling (A)