MMP Inhibitor III

Biochem/physiol Actions

Target IC₅₀: 7.4 nM, 2.3 nM, 135 nM, 10-100 nM, 1-10 nM, against MMP-1, MMP-2, MMP-3, MMP-7, and MMP-13, respectively

Reversible: yes

Product does not compete with ATP.

Primary TargetMMP-1

Cell permeable: yes

General description

A homophenylalanine-hydroxamic acid based broad-spectrum cell-permeable, reversible inhibitor of matrix metalloproteinases (supplied as a racemic mixture). Inhibits MMP-1 (IC₅₀ = 7.4 nM), MMP-2 (IC₅₀ = 2.3 nM), MMP-3 (IC₅₀ = 135 nM), MMP-7 (IC₅₀ = 10-100 nM), and MMP-13 (IC₅₀ = 1-10 nM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Covington, M.D., et al. 2006, Am. J. Physiol. Renal. Physiol.290, F43.

Packaging

1 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months (-20°C).

Warning

Toxicity: Standard Handling (A)