MMP-3 Inhibitor I

Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Target IC₅₀: 5 µM against MMP-3

Primary TargetMMP-3

General description

Inhibits the matrix metalloproteinase MMP-3 (IC₅₀ = 5 µM).

Inhibits matrix metalloproteinase-3 (stromelysin) (IC₅₀ = 5 µM). The inhibitor is based on a segment from the conserved region of the NH₂-terminal propeptide domain.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Fotouhi, N., et al. 1994. J. Biol. Chem. 269, 30227.Hanglow, A.C., et al. 1993. Agents Actions 39, C148.

Packaging

5 mg in Plastic ampoule

Physical form

Supplied as a trifluroacetate salt.

Reconstitution

Following recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for 1-2 weeks at -20°C.

Sequence

Ac-Arg-Cys-Gly-Val-Pro-Asp-NH₂

Warning

Toxicity: Standard Handling (A)