Application

Thromboplastin from rabbit has been used:as a standard in tissue factor procoagulant activity assay (TF-PCA)in pulmonary embolism assayas a positive control in clotting assay using human plasma

Biochem/physiol Actions

Thromboplastin from rabbit might be used to produce disseminated intravascular coagulation (DIC) in animal models.

Thromboplastin (Tissue factor) is a transmembrane protein, the chief in vivo activator of blood coagulation that leads to thrombin generation and fibrin deposition. It is also important in the activation of the coagulation protease cascade and is involved in the lethality of sepsis.,

Packaging

One vial contains 3-4 mg thromboplastin.

Reconstitution

Reconstitute the content of 1 vial in 4 ml 10 mm CaCl₂