p21WAF1 (DCS-60.2); 0.1ml; con

Code: 421M-14 D2-231

General description

p21 is a nuclear 21 kD protein, a product of the WAF1/CIP1 gene. It is a cyclin-dependent kinase inhibitor 1A (p21, Cip1), also known as CDKN1A, which in ...


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€181.50 EACH
€223.25 inc. VAT

General description

p21 is a nuclear 21 kD protein, a product of the WAF1/CIP1 gene. It is a cyclin-dependent kinase inhibitor 1A (p21, Cip1), also known as CDKN1A, which in humans is encoded by the CDKN1A gene located on chromosome (6p21.2). It is a constituent of a large complex of nuclear proteins, including cyclins, cyclin dependent kinases, and PCNA. Cell cycle progression is regulated by cyclins and their cognate Cdks. p21 inhibits the activity of each member of the cyclin/Cdk family. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma).

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Linkage

p21WAF1 Positive Control Slides, Product No. 421S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

For Technical Service please contact: 800-665-7284 or email: [email protected]

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide

Preparation Note

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Quality

IVDIVDIVDRUO

antibody formdiluted ascites fluid
antibody product typeprimary antibodies
biological sourcemouse
cloneDCS-60.2, monoclonal
conjugateunconjugated
controlcolon
descriptionFor In Vitro Diagnostic Use in Select Regions (See Chart)
formbuffered aqueous solution
Gene Informationhuman ... CDKN1A(1026)
isotypeIgG2a
manufacturer/tradenameCell Marque
packagingvial of 0.5 mL concentrate (421M-15), vial of 1.0 mL concentrate (421M-16), vial of 0.1 mL concentrate (421M-14), bottle of 1.0 mL predilute (421M-17), bottle of 7.0 mL predilute (421M-18)
Quality Level100, 500
shipped inwet ice
species reactivityhuman
storage temp.2-8°C
technique(s)immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
visualizationnuclear
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