General description
An aminoindazole compound that potently inhibits the activity of both the wild-type JAK2 and the constitutively active V617F mutant (IC50 = 78 and 206 nM, respectively) frequently found in patients with clonal polycythemia vera, essential thrombocytosis, and chronic idiopathic myelofibrosis, while exhibiting much reduced activity against JAK3 (IC50 = 2.93 µM).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Antonysamy, S., et al. 2008. Bioorg. Med. Chem. Lett.19, 279.
Packaging
Packaged under inert gas
5 mg in Plastic ampoule
Warning
Toxicity: Standard Handling (A)
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