Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary TargetInterleukin-1 receptor-associated kinases

Target IC₅₀: 300 nM and 200 nM for IRAK-1 and -4

Cell permeable: yes

General description

A cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC₅₀ = 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC₅₀ >10 µM), including lck and src. Also available as a 25 mM solution in DMSO (Cat. No. 407602).

A cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC₅₀ = 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC₅₀ >10 µM), including lck and src.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Bhattacharyya, S., et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol.293, G429.Powers, J.P., et al. 2006. Bioorg. Med. Chem. Lett.16, 2842.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Warning

Toxicity: Harmful (C)