Biochem/physiol Actions

Cell permeable: no

Reversible: yes

Product does not compete with ATP.

Target K_i: 1 nM against caspase-8

General description

Potent, reversible granzyme B and caspase-8 inhibitor.

A potent, reversible inhibitor of granzyme B and caspase-8 (K_i = 1 nM). Also inhibits caspase-1 (﹤6 nM), caspase-6 (5.6 nM), and caspase-10 (27 nM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Gao, C.F., et al. 2001. Exp. Cell. Res.265, 145.Garcia-Calvo, M., et al. 1998. J. Biol. Chem.273, 32608.Han, Z., et al. 1997. J. Biol. Chem. 272, 13422.

Packaging

1 mg in Plastic ampoule

Sequence

Ac-Ile-Glu-Thr-Asp-CHO

Warning

Toxicity: Standard Handling (A)