Biochem/physiol Actions

Primary TargetSelective serotonin re-uptake inhibitor

Reversible: no

Product does not compete with ATP.

Cell permeable: yes

General description

A cell-permeable phenylpropylamine derived anti-depressant that acts as a selective serotonin re-uptake inhibitor (SSRI). Reported to modulate the proliferation of T-cells by increasing the Ca²⁺ influx and thereby influencing the activities of protein kinase A (PKA) and protein kinase C (PKC). Also shown to regulate the phosphorylation of DARPP-32 (dopamine-and cAMP-regulated phosphoprotein of M_r 32,000) and AMPA (A-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors. Shown to trigger oxidative stress-induced apoptotic cell death. Also reported to initiate signaling pathways in neuronal cells leading to activation of ERK and NF-κB.

A cell-permeable phenylpropylamine derived anti-depressant that acts as a selective serotonin re-uptake inhibitor (SSRI). Reported to modulate the proliferation of T cells by increasing the Ca²⁺ influx thereby influencing the activities of protein kinase A (PKA) and protein kinase C (PKC). Inhibits leak K⁺ currents in a reversible and voltage-independent manner (IC₅₀ = 780 nM). Also shown to regulate the phosphorylation of DARPP-32 (dopamine-and cAMP-regulated phosphoprotein of Mr 32,000) and AMPA (A-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors. Triggers oxidative stress-induced apoptotic cell death and initiates signaling pathways in neuronal cells leading to an activation of ERK and NF-κB.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Bartholoma, P., et al. 2002. Biochem. Pharmacol.63, 1507.Bian, J.T., et al. 2002. Eur. J. Pharmacol.453, 159.Zhang, A., et al. 2002. J. Med. Chem.45, 1930.Svenningsson, P., et al. 2002. Proc. Natl. Acad. Sci. USA99, 3182.Edgar, V.A., et al. 1999. Eur. J. Pharmacol.372, 65.

Packaging

Packaged under inert gas

25 mg in Plastic ampoule

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Harmful (C)