FABP4 Inhibitor

Code: 341310-5MG D2-231

General description

A cell-permeable biphenylazolo-oxyacetate that acts as a potent and selective inhibitor of adipocyte Fatty-Acid-Binding Protein (aFABP/aP2) by targeting i...


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€182.20 EACH
€224.11 inc. VAT

General description

A cell-permeable biphenylazolo-oxyacetate that acts as a potent and selective inhibitor of adipocyte Fatty-Acid-Binding Protein (aFABP/aP2) by targeting its fatty acid-binding pocket (Ki = ﹤2 nM in a competitive binding assay using 1,8-ANS), while exhibiting much lower affinity for muscle and epidermal FABP′s (Ki = 250 nM and 350 nM, respectively). Shown to effectively block foam cell transformation and the cellular expression of inflammatory mediators in aP2-positive, but not aP2-negative, THP-1 macrophage in vitro, as well as improve the glucose metabolism and insulin sensitivity in mice in vivo.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Furuhashi, M., et al. 2007. Nature447, 959.Sulsky, R., et al. 2007. Bioorg. Med. Chem. Lett.17, 3511.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Standard Handling (A)

assay≥98% (HPLC)
colorwhite
formsolid
manufacturer/tradenameCalbiochem®
Quality Level200
shipped inambient
solubilityDMSO: 50 mg/mL, methanol: 50 mg/mL, ethanol: 20 mg/mL
storage conditionprotect from light, OK to freeze
storage temp.2-8°C
Cas Number300657-03-8
This product has met the following criteria to qualify for the following awards:



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