General description

A cell-permeable semicarbazone compound that inhibits the GTPase activity of dynamin1/2 (IC₅₀ ~15 µM) and Drp1, while exhibiting no significant effect against two other small GTPases, MxA and Cdc42. Dynasore has been used to elucidate the roles of dynamin in endocytosis mediated by both clathrin-coated and synaptic vesicles. The inhibitition is noncompetitive with respect to GTP and the inhibitor target site presumably resides in the GTPase domain. Shown to inhibit removal of both wt and δF508-CFTR from the plasma membrane.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Young, A., et al. 2009. Biochem. J., In press.Nankoe, S.R., and Sever, S. 2006. Trends Cell Biol.16, 607.Newton, A.J., et al. 2006. Proc. Natl. Acad. Sci. USA103, 17955.Macia. E., et al. 2006. Dev. Cell10, 839.

Packaging

Packaged under inert gas

10 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Environmental Hazard (N)