General description
A cyanopyrrolidine compound that acts as a potent DPP IV inhibitor (IC50 = 3, 5, 8, and 8 nM in inhibiting rat, human, monkey, and canine DDP IV, respectively). Oral administration of K579 in rats in vivo has been shown to reduce blood DPP IV activity and augment GLP-1 and insulin response after glucose intake and significantly reduce plasma glucose concentration.
Please note: 328.4 is the anhydrous molecular weight; please refer to the vial label for the lot-specific hydration and molecular weight.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Takasaki, K., et al. 2004. Eur. J. Pharmacol.505, 237.Takasaki, K., et al. 2004. Eur. J. Pharmacol.486, 335.Takasaki, K., et al. 2004. J. Pharmacol. Sci.95, 291.
Please note: 328.4 is the anhydrous molecular weight; please refer to the vial label for the lot-specific hydration and molecular weight.
Packaging
5 mg in Glass bottle
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
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