Biochem/physiol Actions

Target IC₅₀: 12 µM against PKC

Reversible: yes

Product does not compete with ATP.

Primary TargetPKC

Cell permeable: yes

General description

A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC₅₀ = 12 µM) and stimulates Src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells. An inhibitor of sphingosine kinase.

A cell-permeable and reversible inhibitor of protein kinase C (IC₅₀ = 12 µM) and enhances src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Cuvillier, O., et al. 1996. Nature381, 800.Ohta, H., et al. 1995. Cancer Res.55, 691.Kimura, S., et al. 1992. Biochem. Pharmacol.44, 1585.Hanada, K., et al. 1991. Biochemistry30, 11682.Igarashi, Y., et al. 1990. J. Biol. Chem.265, 5385.

Packaging

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.

Warning

Toxicity: Irritant (B)