276M-95 Display Image

Ksp-cadherin (MRQ-33); 0.5ml;

Code: 276M-95 D2-231

General description

Kidney-specific cadherin (Ksp-cadherin) is a novel, kidney-specific member of the cadherin family of cell adhesion molecules. Within the kidney, Ksp-cadhe...


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€477.41 EACH
€587.21 inc. VAT

General description

Kidney-specific cadherin (Ksp-cadherin) is a novel, kidney-specific member of the cadherin family of cell adhesion molecules. Within the kidney, Ksp-cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels. Different cadherins, including E-cadherin, cadherin-6, and N-cadherin, have been investigated in renal cell cancers, demonstrating possible correlations of tumor dedifferentiation and the presence of lymph node metastasis with loss of cadherins. Mazal et al. investigated the utility of using Ksp-cadherin to distinguish chromophobe renal cell carcinoma from oncocytoma. He found a membranous pattern of staining in 96% of 30 chromophobe carcinomas, and in only 6% of 31 oncocytomas leading them to conclude that this is a useful antibody in differentiating these two lesions. Shen et al., on the other hand, found Ksp-cadherin positivity in 100% of 13 chromophobe RCCs, and 95% of 20 oncocytomas.Associated products: CK7, RCC

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Linkage

Ksp-cadherin Positive Control Slides, Product No. 276S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide

Preparation Note

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Quality

IVDIVDIVDRUO

antibody formculture supernatant
antibody product typeprimary antibodies
biological sourcemouse
cloneMRQ-33, monoclonal
conjugateunconjugated
controlkidney
descriptionFor In Vitro Diagnostic Use in Select Regions (See Chart)
formbuffered aqueous solution
Gene Informationhuman ... CDH16(1014)
isotypeIgG1
manufacturer/tradenameCell Marque
packagingbottle of 7.0 mL predilute (276M-98), bottle of 1.0 mL predilute (276M-97), vial of 0.1 mL concentrate (276M-94), vial of 1.0 mL concentrate (276M-96), vial of 0.5 mL concentrate (276M-95)
Quality Level100, 500
shipped inwet ice
species reactivityhuman
storage temp.2-8°C
technique(s)immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
visualizationmembranous
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276M-94
Unit:EACH
List Price: €211.92
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276M-96
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List Price: €699.07
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276M-97
Unit:EACH
List Price: €185.12
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276M-98
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List Price: €568.75
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